SARS Vaccine
Amino acid substitution in SARS coronavirus spike protein disrupts binding
Published in Vaccine Weekly, July 5th, 2006
According to a study from the United States, "The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has two major functions: interacting with the receptor to mediate virus entry and inducing protective immunity. Coincidently, the receptor-binding domain (RBD, residues 318-510) of SAR-CoV S protein is a major antigenic site to induce neutralizing antibodies. Here, we used RBD-Fc, a fusion protein containing the RBD and human IgG1 Fc, as a model in the studies and found that a single...
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Source: Vaccine Weekly (2006-07-05)
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