Published in Vaccine Weekly, July 5th, 2006
"We explored the possibility of using normal adult rhesus macaques for the preclinical assessment of safety, immunogenicity, and efficacy of newly developed vaccines against Streptococcus pneumoniae infection of the lung. Our primary objective was to determine whether an intra-bronchial inoculum of at least 106S. pneumoniae colony-forming units, or one as high as 108-109 organisms, could detectably survive in rhesus macaques for a period longer than one to two weeks," researchers in the United States report.
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