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Tuberculosis Vaccine

Helminths do not affect tuberculin reactivity, but BCG influences hookworm prevalence

Published in Vaccine Weekly, July 12th, 2006

Helminths fail to influence tuberculin reactivity, but BCG influences hookworm prevalence.

According to a study from the United States and India, "The prevalence of helminth and tuberculosis infections is high in South India, whereas Bacille-Calmette-Guerin (BCG) vaccine efficacy is low. Our aim was to determine whether concurrent helminth infection alters the ability to mount a delayed-type hypersensitivity response to tuberculin."

"In a cross-sectional study in southern India, individuals 6-65 years of age were screened for intestinal helminths, circulating filarial antigenemia, tuberculin reactivity, active tuberculosis, and history of BCG...

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