Herpes Vaccine

CpG oligodeoxynucleotide is potent adjuvant for vaccination against genital herpes

Published in Vaccine Weekly, July 12th, 2006

Mucosal administration of CpG oligodeoxynucleotide (ODN) elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes.

Scientists in Sweden and the United States report, "Although sexually transmitted pathogens are capable of inducing pathogen-specific immune responses, vaginal administration of nonreplicating antigens elicits only weak, nondisseminating immune responses. The present study was undertaken to examine the potential of CpG-containing oligodeoxynucleotide (CpG ODN) for induction of chemokine responses in the genital tract mucosa and also as a vaginal...

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Source: Vaccine Weekly (2006-07-12)

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