Cholera Vaccine

Complex conjugates based on Vibrio cholerae lipopolysaccharide antigen show promise for vaccines

Published in Vaccine Weekly, July 12th, 2006

Investigators have identified complex conjugates based on Vibrio cholerae O1 Ogawa lipopolysaccharide antigen that show promise as vaccine candidates.

Scientists writing in the journal Clinical and Experimental Immunology report, "Host protection by humoral immunity against Vibrio cholerae O1 confers lipopolysaccharide (LPS)-specific vibriocidal antibodies. Levels of relevant specific antibodies are closely related to complement-mediated inactivation of the vibrios inoculum, especially on the mucosal surface of intestine. We have tested complex V. cholerae O1 Ogawa-detoxified lipopolysaccharide (dLPS) conjugates. The first conjugate contained...

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Source: Vaccine Weekly (2006-07-12)

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