Allergy & Immunology
CD28 costimulation induces incomplete activation response in EBV-specific T cells
Published in Vaccine Weekly, July 19th, 2006
"Expression of tumor antigen-specific chimeric receptors in T lymphocytes can redirect their effector functions towards tumor cells. Integration of the signaling domains of the costimulatory molecule CD28 into chRec enhances antigen-specific proliferation of polyclonal human T cell populations," scientists in Germany report.
According to B. Altvater and colleagues at the University of Munster, "While CD28 plays an essential role in the priming of naive CD4+ T cells, its contribution to effector...
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Source: Vaccine Weekly (2006-07-19)
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