Vaccine Development
Tobacco mosaic virus particles were used for display of vaccine antigens
Published in Vaccine Weekly, July 26th, 2006
According to recent research published in the journal Virology, "Display of peptides or proteins in an ordered, repetitive array, such as on the surface of a virus-like particle, is known to induce an enhanced immune response relative to vaccination with the 'free' protein antigen. The coat protein of tobacco mosaic virus (TMV) can accommodate short peptide insertions into the primary sequence, but the display of larger protein moieties as genetic fusions to the capsid protein has not been possible."
"We employed a...
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Source: Vaccine Weekly (2006-07-26)
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