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Influenza Vaccine

High doses of influenza vaccine safe and immunogenic in elderly persons

Published in Vaccine Weekly, July 26th, 2006

High doses of flu vaccine are safe and immunogenic in elderly persons.

According to a recently published study from the United States, "Immune responses after influenza immunization are reduced in elderly individuals, the group at greatest risk for complications and death after influenza. Improved vaccines are needed to address this problem."

"Ambulatory individuals 65 years and older (N=202) were assigned randomly to receive a single intramuscular injection of the 2001-2002 formulation of trivalent inactivated influenza vaccine containing 15, 30, or 60 mcg of hemagglutinin per strain (up to 180 mcg total per dose) or placebo.

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