Natural Products
Cytotoxic constituents of Achillea clavennae analyzed
Published in Vaccine Weekly, July 26th, 2006
According to a study from Serbia Montenegro, "Examination of the aerial parts of Achillea clavennae afforded 8 guaianolides (1-8), 3 bisabolenes (9 11), 4 flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods."
"The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a...
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Source: Vaccine Weekly (2006-07-26)
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