Multiple Myeloma Pathogenesis
Oncogenic RAS mutations in myeloma cells induce cox-2 expression
Published in Vaccine Weekly, August 2nd, 2006
"Oncogenic RAS expression occurs in up to 40% of multiple myeloma (MM) cases and correlates with aggressive disease. Since activated RAS induces cyclooxygenase-2 (cox-2) expression in other tumor models, we tested a role for cox-2 in mutant RAS-containing MM cells," researchers in the United States report.
We used the ANBL-6 isogenic MM cell lines in which the IL-6-dependent parental line becomes cytokine independent following transfection with mutated N-RAS or K-RAS," explained Bao Hoang and...
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Source: Vaccine Weekly (2006-08-02)
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