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Pancreatic Cancer

Connective tissue growth factor-specific monoclonal antibodies inhibit pancreatic tumors

Published in Vaccine Weekly, August 9th, 2006

Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis.

According to recent research published in the journal Cancer Research, "Pancreatic cancer is highly aggressive and refractory to most existing therapies. Past studies have shown that connective tissue growth factor (CTGF) expression is elevated in human pancreatic adenocarcinomas and some pancreatic cancer cell lines. To address whether and how CTGF influences tumor growth, we generated pancreatic tumor cell lines that over-express different levels of human CTGF."

"The effect of CTGF overexpression on cell proliferation was...

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