Published in Vaccine Weekly, August 9th, 2006
Researchers in England report, "We investigated the potential of a new family of lipidic peptide dendrimers in protein transduction into cultured cells."
"Dendrimer-protein interaction was determined by gel retardation assays using purified recombinant protein. To assess intracellular protein delivery, two marker proteins were used: recombinant firefly luciferase and a Cy3-labeled monoclonal antibody to the c-myc proto-oncogene. Protein delivery was determined by luciferase assays and fluorescence microscopy, respectively," explained Henry K. Bayele and colleagues at University College London...
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