Vaccine Weekly

Avian Influenza Vaccine - Reverse-genetics-produced H5N1 bird flu vaccine protects ferrets

Candidiasis Vaccine - Vaccines show promise against disseminated and mucosal candidiasis

Chickenpox Vaccine - Live varicella vaccine benefits HIV-infected children with depressed CD4+ T cell counts

Polio Vaccine - Inactivated poliovirus vaccine derived from Sabin strains has been developed

Polio Vaccine - Worldwide oral polio vaccine cessation strategy is presented

Adenovirus Pathogenesis - Adenovirus type 2 and type 5 E1A genes are expressed at different levels

Adverse Drug Reaction - Chronic exposure of tumor cells to PD98059 decreased inhibitory effect

Allergy & Immunology - Common vaccine antigens inhibit allergen-induced airway hyper-responsiveness

Allergy & Immunology - Complement component plays key role in Th1 and Th2 responses to antigen

Allergy & Immunology - Der p 1 peptide on virus-like particles is safe and immunogenic in adults

Allergy & Immunology - Nanogram doses of DNA vaccines inhibit type I allergic responses

Antitumor Therapy - Human-mouse chimeric antibody against transferrin receptor has a strong antitumor effect

Apoptosis - Gastric cancer apoptosis inhibited by down regulating mitotic arrest deficient 2

Avian Influenza Vaccine - Dual expression of HA protein of H5N2 avian influenza virus has been achieved in a baculovirus system

Breast Cancer - Lymphatic mapping enables real-time intraoperative detection of lymphatic metastases

Breast Cancer Vaccine - DNA vaccine targeting angiomotin suppresses tumor growth

Business Update - CytoDyn joins fight against flu, U.S. Senator Pete Domenici calls effort promising for economy

Business Update - CytRx President and CEO Steven Kriegsman talks to The Wall Street Transcript

Business Update - Novartis builds influenza vaccine manufacturing site in North Carolina

Cancer Gene Therapy - Prostate cancer development suppressed by adenoviral-mediated vaccine

Cancer Therapy - Anticancer properties of flavonoids isolated from leaf of Patrinia villosa Juss. evaluated

Cancer Therapy - Thiazolidinedione-derived novel therapeutic agents proposed for cancer therapy

Cancer Vaccine - Antibodies to MHC class I chain-related protein A stimulate antitumor cytotoxicity

Cancer Vaccine - Beta-hCG 109-118 enhances antitumor effects of beta-hCG C-terminal peptide

Cancer Vaccine - CD8+ T cell memory in tumor immunology and immunotherapy is reviewed

Cancer Vaccine - Exosomes from heat-shocked lymphoma cells induce antitumor immunity

Cancer Vaccine - Retrogen vaccine generates high titer survivin antibody responses

Cancer Vaccine - Vaccine induces immunity to squamous carcinoma

Colon Cancer - Intracel gets SPA from U.S. FDA for pivotal Phase III study of OncoVAX colon cancer vaccine

DNA Vaccine - Cationic lipids for gene delivery in vitro and in vivo are reviewed

DNA Vaccine - Toll-like receptor adaptor molecules enhance immune responses against influenza and tumors

Dendritic Cells - Mannan derivatives induce maturation of mouse dendritic cells

Diarrhea Surveillance - Enterotoxigenic Escherichia coli most frequently isolated pathogen in U.S. military in Egypt

Drug Development - 2-methoxyestradiol and its analogs evaluated as probes of anti-tumor mechanisms

Drug Development - Crucell announces suspension of Aerugen clinical development

Enterovirus Vaccine - Anadis gets key regulatory approval received for enterovirus 71 vaccine program

Finance - MedImmune reports Q2 2006 revenues of $73 million, net loss of $63 million

Gastroenterology - Wyeth, Progenics report methylnaltrexone for postop ileus gets U.S. FDA fast track status

HIV/AIDS Awareness - Critically acclaimed "Live With It" debuts second episode, focusing on millions living life HIV+

HIV/AIDS Therapy - Gilead cuts AIDS drugs prices in middle-income countries

HIV/AIDS Therapy - Standard operating procedures are needed for HIV-specific T cells in gamma interferon ELISPOT

HIV/AIDS Therapy - Survey shows twice as many physicians than patients are concerned about HIV drug resistance

HIV/AIDS Therapy - U.S. FDA approves first once-a-day three-drug combination tablet for treating HIV-1

HIV/AIDS Vaccine - Genetic stability of HIV-1 variant is improved by mutations that restrain evolution

HIV/AIDS Vaccine - HIV-1SF162-derived envelope gp140 proteins do not protect against SHIV

HIV/AIDS Vaccine - Vaccination preserves CD4 memory T cells during acute SIV challenge

Hepatitis B Therapy - Biodegradable nanoparticle delivery of a peptide induces immune responses

Hepatitis B Vaccine - Two hepatitis B vaccines compared in healthy infants

Hepatitis B Virus - Hepatitis B virus capsid-like particles stimulate protective antibody responses

Hepatocellular Carcinoma - Amphiregulin contributes to phenotype of hepatocellular carcinoma cells

Human Papillomavirus Vaccine - Molecular variants of human papillomavirus are focus of review

Huntington Disease Vaccine - Glial cell line-derived neurotrophic factor improves behavior in Huntington disease

Influenza Vaccine - Immunoglobulin mucin-1 antibodies and inactivated influenza enhances cross-strain reactivity

Influenza Vaccine - Multifaceted roles for CD4+ T cells in protective immunity to influenza are reviewed

Influenza Virus - U.S. FDA issues complete response letter to MedImmune's new formulation of FluMist

Listeriosis Vaccine - CD8+ central memory T cells develop into protective Listeria-specific effector memory T cells

Lung Cancer - DNA vaccine was safe but not particularly effective for lung cancer

Malaria Vaccine - TNF-alpha was associated with fetal death in malaria during pregnancy

Melanoma - IL-23 and IL-27 exert different vaccine effects on poorly immunogenic melanoma

Meningitis Risk Factors - No risk factors were identified for Haemophilus influenzae type b carriage in Alaska

Meningitis Vaccine -  Haemophilus influenzae type b vaccine is needed in Japan to prevent severe Hib infections

Meningitis Vaccine - Meningococcal vaccination primes for immunologic memory in vaccine-naive adults

Meningococcal Vaccine - Effectiveness analyses underestimate meningococcal vaccine protection of infants

Mergers & Acquisitions - Chinese developer of human vaccines Techedge Inc. acquires China BioPharma Limited

Mycobacteria Vaccine - Mycobacteria impair function of dendritic cells through IL-1 beta

Papillomavirus - Human papillomavirus in cervical lesions genotyped

Parvovirus Vaccine - Restricted T cell receptor dominates T cell response to parvovirus B19

Pituitary Gland Cancer - Adenoviral vectors encoding TNF-alpha and FasL induce apoptosis of pituitary cells

Pneumococcal Vaccine - Adhering to current recommendations would prevent invasive pneumococcal disease

Pneumococcal Vaccine - Cost-effectiveness of pneumococcal conjugate vaccine is increased due to herd effects

Pneumococcal Vaccine - Prevenar protects children with chronic or recurrent lung disease

Polio Vaccine - First decade of studies and trials with polio vaccine are reviewed

Polio Vaccine - GlaxoSmithKline view of inactivated polio vaccine is presented

Polio Vaccine - Long-term excretors of vaccine-derived poliovirus are reported

Polio Vaccine - Methods for interrupting poliovirus transmission are presented

Polio Vaccine - Persistent poliovirus excretion is unusual in HIV-infected patients

Polio Vaccine - Poliovirus facilities pose risk to surrounding communities

Polio Vaccine - Rapid manufacture of oral polio vaccines was accomplished for supply to endemic countries

Polio Vaccine - Strategy for technology transfer of Sabin vaccine to developing countries is outlined

Poxvirus Vaccine - Cross-reactive variant peptide encoded by mousepox virus has been identified

Prostate Cancer - Liposomal vaccine increases prostate-specific antigen doubling time after prostatectomy

Protein Production - Method for conformation-specific affinity purification of proteins has been developed

Protein Production - Vector for large-scale, high-throughput purification of recombinant proteins has been developed

Respiratory Medicine - T cell memory and recall responses to respiratory virus infections are focus of review

Skin Cancer - Melanoma vaccine is focus of Baylor Institute for Immunology Research grant

Smallpox Vaccine - Antibody prevents poxvirus from forming pock lesions that promote virus transmission

Smallpox Vaccine - Human leukocyte antigen-A2-restricted CD8+ CTL responses to vaccinia virus epitope are examined

Smallpox Vaccine - Immunity against secondary poxvirus infection depends on antibody, not on CD4 or CD8 function

Smallpox Vaccine - Immunity and immunological memory following smallpox vaccination are reviewed

Streptococcal Vaccine -  Streptococcus pneumoniae serotype distribution in Switzerland is reported

Transplant Medicine - Bird flu pandemic may increase mortality in transplantation patients