Allergy & Immunology
Der p 1 peptide on virus-like particles is safe and immunogenic in adults
Published in Vaccine Weekly, August 16th, 2006
"In mice, highly repetitive antigens, such as those present on bacterial or viral surfaces, efficiently cross-link B-cell receptors and therefore induce strong IgG responses. In this study we covalently coupled a synthetic 16-amino-acid sequence of the allergen Der p 1 to a virus-like particle derived from the bacteriophage Q beta (Q beta-Der p 1)," investigators in Switzerland report.
"We evaluated the safety and immunogenicity of Q beta-Der p 1 in human subjects and compared different doses and routes of immunization," said Thomas M. Kundig and colleagues...
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Source: Vaccine Weekly (2006-08-16)
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