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Leukemia

Researchers' findings from the United States and India advance leukemia research

Published in Vaccine Weekly, August 30th, 2006

Investigators in the United States and India have published new leukemia data.

Study 1: Acute myeloid leukemia was associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque.

According to scientists in the United States, "We report, for the first time, a replication-defective retroviral vector-associated neoplasia in a nonhuman primate. Five years after transplantation with CD34+ cells transduced with a retroviral vector expressing enhanced green fluorescent protein (eGFP) and a drug-resistant variant of the dihydrofolate reductase gene (L22Y), a rhesus macaque developed a fatal myeloid sarcoma, a type of acute...

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