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Pancreatic Cancer

Oncolysis of pancreatic tumor cells by gamma 34.5-deleted HSV-1 relies on PI 3-kinase pathway

Published in Vaccine Weekly, August 30th, 2006

Oncolysis of pancreatic tumor cells by a gamma 34.5-deleted HSV-1 does not rely upon Ras-activation, but on the PI 3-kinase pathway.

According to recent research from Italy, "The ability of viruses to selectively target, replicate within, and destroy tumor cells without deleterious effects in normal cells (oncolysis), makes the use of viruses as an attractive tool for cancer treatment. Pancreatic adenocarcinoma, being insensitive to traditional therapy and having a rather poor prognosis, represents a suitable target to evaluate viral oncolysis as a novel therapeutic approach."

"Herpes simplex virus (HSV) has been reported to produce an oncolytic...

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