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Vaccine Safety

Nine DTP vaccines were assessed with reduced antigen as a second-year booster

Published in Vaccine Weekly, September 6th, 2006

Investigators assess nine candidate DTP vaccines with reduced amount of antigen and/or without adjuvant as a fourth dose in the second year of life in a recent issue of Vaccine.

According to a report from Germany, "The incidence of local reactions to diphtheria-tetanus-acellular pertussis (DTaP) vaccines in infants and toddlers increases with each subsequent dose, and entire thigh swellings (ETS) have been reported. Lowering the amount of antigen or of adjuvant may decrease the reactogenicity of DTaP while maintaining a protective immune response."

"Following priming with three doses of a DTAP vaccine during infancy, the safety, reactogenicity...

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