Vector Development
Adenovirus type 5 interactions with blood cells compromise systemic delivery
Published in Vaccine Weekly, September 6th, 2006
According to a study from England, "Intravenous delivery of adenovirus vectors requires that the virus is not inactivated in the bloodstream. Serum neutralizing activity is well documented, but we show that type 5 adenovirus also interacts with human blood cells."
"Over 90% of a typical virus dose binds to human (but not murine) erythrocytes ex vivo, and samples from a patient administered adenovirus in a clinical trial showed that over 98% of viral DNA in the blood was cell associated," said Mark Lyons at the University of Oxford and collaborators in England. "In...
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Source: Vaccine Weekly (2006-09-06)
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