Cancer Therapy

Gene-modified dendritic cells stimulate specific T cell responses

Published in Vaccine Weekly, September 20th, 2006

According to recently published research from the United States, interleukin (IL)-12p70 and IL-18 gene-modified dendritic cells (DCs) loaded with tumor antigen-derived peptides or recombinant protein effectively stimulate specific Type-1 CD4+ T-cell responses from normal donors and melanoma patients in vitro.

"Although CD4+ Type-1T helper (Th1) cells secreting interferon-gamma (IFN-gamma) appear to play an essential role in promoting durable antitumor immunity, we have previously shown that patients with cancer exhibit dysfunctional Th1-type responses against epitopes derived from tumor antigens, such as MAGE-A6.

"Here, we engineered human DCs to...

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Source: Vaccine Weekly (2006-09-20)

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