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Rotavirus Vaccine

Bovine-human rotavirus reassortant tetravalent vaccine safe and immunogenetic

Published in Vaccine Weekly, October 4th, 2006

A bovine-human rotavirus reassortant tetravalent vaccine is safe and immunogenetic in children.

"Live oral rhesus-rhesus-human rotavirus reassortant tetravalent (RRV-TV) vaccine was efficacious against rotavirus gastroenteritis but was withdrawn because of a rare association with intussusception.

"A corresponding tetravalent (types G1, G2, G3, and G4) reassortant vaccine based on bovine-human (UK) rotavirus reassortant tetravalent (BRV-TV) vaccine was developed concurrently," scientists in Finland report.

According to researchers, "Before the withdrawal of RRV-TV vaccine, parallel placebo-controlled trials of BRV-TV vaccine...

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