HIV/AIDS Vaccine
Transport-competent influenza HA/HIV Env chimeric protein is antigenic
Published in Vaccine Weekly, October 18th, 2006
"The transmembrane subunit (gp41) of the HIV Env glycoprotein contains conserved neutralizing epitopes which are not well-exposed in wild-type HIV Env proteins. To enhance the exposure of these epitopes, a chimeric protein, HA/gp41, in which the gp41 of HIV-1 89.6 envelope protein was fused to the C-terminus of the HA1 subunit of the influenza HA protein, was constructed," researchers in the United States report.
"Characterization of protein expression showed that the HA/gp41 chimeric proteins were expressed on cell surfaces and formed trimeric oligomers, as...
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Source: Vaccine Weekly (2006-10-18)
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