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Myocarditis

Virus receptor trap neutralizes coxsackievirus in viral myocarditis

Published in Vaccine Weekly, October 18th, 2006

A virus receptor trap neutralized coxsackievirus in experimental murine viral myocarditis.

According to researchers in South Korea, "The coxsackie and adenovirus receptor (CAR) and the decay-accelerating factor (DAF) are receptors for coxsackievirus B3 (CVB3), which is known as the major cause of human viral myocarditis. We investigated the potential for therapeutic use of soluble virus receptor fusion proteins."

"We designed and generated a novel virus receptor trap (hCAR-hDAF:Fc) consisting of both CVB3 receptors and the Fc portion of human IgG, and evaluated its antiviral effects in experimental CVB3 myocarditis," explained Byung-Kwan Lim and...

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