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Ovarian Cancer Pathogenesis

Pigment epithelium-derived factor inhibits growth of ovarian cancer

Published in Vaccine Weekly, October 18th, 2006

Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells.

According to scientists China, "Epithelial ovarian carcinoma is the most lethal gynecological cancer. However, little is known about the molecular mechanisms underlying the disease development and progression. In this study, we found that the expression of pigment epithelium-derived factor (PEDF) was greatly reduced in ovarian tumors and in ovarian cancer cell lines when compared with their normal precursor, ovarian surface epithelium (OSE)."

"In addition, we showed that exogenous PEDF inhibited the growth of...

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