Published in Vaccine Weekly, October 18th, 2006
According to scientists in Germany, "Adenovirus-based (Ad) vectors are used widely for experimental gene transfer to the CNS. Ad transduce many cell types including post-mitotic neurons. However, their use for CNS gene transfer is limited due to the host immune response elicited."
"Furthermore, the extensive distribution of the primary cellular receptor for Ad, the coxsackievirus and adenovirus receptor (CAR), allows adenoviral vectors to infect a broad range of host cells which may be disadvantageous...
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