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Apoptosis

Antigen presentation pathways contribute differentially to vaccinia virus immunogenicity

Published in Vaccine Weekly, October 25th, 2006

Antigen presentation pathways may contribute differentially to vaccinia virus and modified vaccinia virus Ankara immunogenicity.

According to a study from the United States, "Modified vaccinia virus Ankara (MVA) is an attenuated strain of vaccinia virus (VV) that has attracted significant attention as a candidate viral vector vaccine for immunization against infectious diseases and treatment of malignancies.

"Although MVA is unable to replicate in most nonavian cells, vaccination with MVA elicits immune responses that approximate those seen after the administration of replication-competent strains of VV. However, the mechanisms by which these viruses...

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