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Lassa Virus Vaccine

Protective Lassa virus epitopes restricted by HLA-A2 have been identified

Published in Vaccine Weekly, October 25th, 2006

Protective Lassa virus epitopes restricted by HLA-A2 have been identified.

According to scientists in the United States, "Recovery from Lassa virus (LASV) infection usually precedes the appearance of neutralizing antibodies, indicating that cellular immunity plays a primary role in viral clearance. To date, the role of LASV-specific CD8(+) T cells has not been evaluated in humans."

J. Botten and colleagues at Scripps Research Institute in La Jolla wrote, "To facilitate such studies, we utilized a predictive algorithm to identify candidate HLA-A2 supertype epitopes from the LASV nucleoprotein and glycoprotein precursor (GPC) genes. We identified three...

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