HIV/AIDS
New findings from the United States in the area of HIV/AIDS detailed
Published in Vaccine Weekly, November 1st, 2006
Study 1: Scientists have developed a method for the selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction.
"Hematopoietic progenitor cells (HPCs) represent an ideal target for gene therapy treatment of human immunodeficiency virus (HIV) infection. However, gene delivery into quiescent HPCs by retroviral or lentiviral vectors remains relatively poor. We evaluated a selection scheme based on the expression of a variant of inosine monophosphate dehydrogenase 2 (IMPDH2), the rate-limiting enzyme in the de novo...
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Source: Vaccine Weekly (2006-11-01)
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