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Poliomyelitis Vaccine

Outbreak of poliomyelitis in China was caused by type 1 vaccine-derived poliovirus

Published in Vaccine Weekly, November 1st, 2006

An outbreak of poliomyelitis in China was caused by type 1 vaccine-derived poliovirus

"In May-July 2004, type 1 vaccine-derived poliovirus (VDPV) was isolated from two case patients with polio and a contact of a third case patient in Guizhou Province. We conducted a field investigation of the outbreak, characterized outbreak isolates, and retrospectively reviewed national polio surveillance data for other VDPVs. Case patients were unimmunized children, 0.9 to 3.2 years old, living in two villages 40 km apart. Immunization coverage in the affected villages was very low," researchers in China report.

"Isolates differed from the Sabin 1 type by 9-11 VP1...

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