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HIV/AIDS Vaccines

Data on HIV/AIDS vaccines reported by researchers at National Institute of Allergy and Infectious Disease

Published in Vaccine Weekly, January 3rd, 2007

Scientists discuss in "Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine" new findings in HIV/AIDS. "Gene-based vaccine delivery is an important strategy in the development of a preventive vaccine for acquired immunodeficiency syndrome (AIDS). Vaccine Research Center (VRC) 004 is the first phase 1 dose-escalation study of a multiclade HIV-1 DNA vaccine," scientists in the United States report.

"VRC-HIVDNA009-00-VP is a 4-plasmid mixture encoding subtype B Gag-Pol-Nef fusion protein and modified envelope (Env) constructs from subtypes A, B, and C. Fifty healthy, uninfected adults were randomized to receive either placebo (n=10) or...

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