Typhoid Vaccines
Studies from University of Maryland yield new data on typhoid vaccines
Published in Vaccine Weekly, March 7th, 2007
A new study, "Cell-mediated immune responses in humans after immunization with one or two doses of oral live attenuated typhoid vaccine CVD 909," is now available. "CVD 909 is a novel live attenuated S. typhi oral vaccine candidate derived from strain CVD 908-htrA which constitutively expresses Vi. Herein we investigated whether the genetic manipulations involved in modifying CVD 908-htrA altered its ability to induce potent T-cell immune responses (CMI) after a single dose (five subjects) and, in a separate trial, whether a second dose (eight subjects) further enhanced its immunogenicity," scientists in the United States report.
"In these clinical trials we...
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Source: Vaccine Weekly (2007-03-07)
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