Gene Therapy
Studies from University of Saskatchewan, Department of Oncology describe new findings in gene therapy
Published in Vaccine Weekly, April 18th, 2007
A report, "Enhanced T-cell immunity induced by dendritic cells with phagocytosis of heat shock protein 70 gene-transfected tumor cells in early phase of apoptosis," is newly published data in Cancer Gene Therapy. "The dual role of heat shock protein 70 (HSP70), as antigenic peptide chaperone and danger signal, makes it especially important in dendritic cell (DC)-based vaccination. In this study, we investigated the impacts of apoptotic transgenic MCA/HSP tumor cells expressing HSP70 on DC maturation, T-cell stimulation and vaccine efficacy," investigators in Saskatoon, Canada report.
"We found that DCs with phagocytosis of MCA/HSP in early phase of apoptosis...
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Source: Vaccine Weekly (2007-04-18)
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