HIV/AIDS
Research from Scripps Research Institute, Department of Immunology yields new findings on HIV/AIDS
Published in Vaccine Weekly, July 25th, 2007
Data detailed in "Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis" have been presented. "The identification of cross-neutralizing antibodies to HIV-1 is important for designing antigens aimed at eliciting similar antibodies upon immunization. The monoclonal antibody (mAb) F425-B4e8 had been suggested previously to bind an epitope at the base of V3 and shown to neutralize two primary HIV isolates," scientists in the United States report.
"Here, we have assessed the neutralization breadth of mAb F425-B4e8 using a 40-member panel of primary HIV-1 and determined the epitope...
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Source: Vaccine Weekly (2007-07-25)
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