Rotavirus
Study results from O.L. Rojas and colleagues broaden understanding of rotavirus
Published in Vaccine Weekly, October 10th, 2007
"In a double blind trial, 319 fully immunized children received two doses of either placebo or 10(6.7) focus-forming units of the attenuated RIX4414 human rotavirus ( RV) vaccine (''all-in-one'' formulation). Plasma RV-specific IgA ( RV IgA), stool RV IgA, and circulating total and RV memory B cells ( CD19(+)IgD(+/-)CD27(+)) with an intestinal homing phenotype (alpha(4)beta(7)+CCR9(+/-)) were measured, after the first and second doses, as potential correlates of protection," scientists in Bogota, Colombia report.
"After the first and/or second dose, 54% of vaccinees and 13% of placebo recipients had plasma RV IgA. Before vaccination, most (95%) of the children ( of both...
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Source: Vaccine Weekly (2007-10-10)
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