Foot and Mouth Disease

Reports summarize foot and mouth disease study results from Huazhong Agricultural University

Published in Vaccine Weekly, October 31st, 2007

"'Because foot-and-mouth disease virus (FMDV) remains a great problem to many livestock of agricultural importance, safe, effective vaccines are in great need. DNA vaccine would be a promising candidate but the design remains to be optimized," scientists writing in the journal Virus Genes report.

"VP1 gene of FMDV strain O/ES/2001 was linked to three copies of either porcine or murine C3d or four copies of a 28-aa fragment of murine C3d containing the CR2 receptor binding domain (M28). The resultant plasmids encoding C3d/M28-VP1 fusion or only VP1 as control were immunized guinea pigs. Both cellular and humoral immune responses were evaluated and protection was...

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Source: Vaccine Weekly (2007-10-31)

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