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DNA Vaccines

Reports summarize DNA vaccines research from N. Li and co-authors

Published in Vaccine Weekly, November 28th, 2007

"In a previous study. it has been shown that a Semliki Forest virus (SFV) replicon vectored DNA vaccine (pSFV1CS-E2) expressing the E2 glycoprotein of classical swine fever virus (CSFV) conferred full protection for pigs immunized three times with 600 mu g of the vaccine. This study was designed to evaluate further the efficacy of the vaccine with lower dosage and fewer inoculations," scientists in Harbin, People's Republic of China report.

"Pigs were immunized twice with 100 mu g of pSFV1CS-E2 (n=5) or control plasmid pSFV1CS (n=3), respectively, and challenged with virulent Shimen strain 6 weeks following the booster immunization. Pigs immunized with pSFV1CS-E2...

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