Fusion Proteins

Research from C.X. Su and co-researchers provides new data on fusion proteins

Published in Vaccine Weekly, December 5th, 2007

"Mycobacterium tuberculosis heat shock protein70 (HSP70) is a major antigen with both chaperone and cytokine functions. It has been used as an adjuvant to induce or potentiate humoral and cellular immunity, both in the form of a mixture with peptide antigens, and as a fusion protein," researchers in Nanjing, People's Republic of China report.

"We have evaluated the effects of HSP70 on foot and mouth virus (FMDV) subunit vaccines. FMDV VP1, and a synthetic multi-epitope FMDV (EG), and VP1-HSP70 and EG-HSP70 fusion proteins were all hetero-logously expressed in the yeast Pichia pastoris, and used as antigen in mice. The recombinant VP1 and EG alone was able to induce both...

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Source: Vaccine Weekly (2007-12-05)

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