Vaccines

Research on vaccines detailed by scientists at University of Texas

Published in Vaccine Weekly, January 2nd, 2008

"Ricin is a plant toxin that is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax), which contains mutations in both known toxic sites, has no residual toxicity at doses at least 800 times the immunogenic dose," investigators in the United States report.

"RiVax without adjuvant given intramuscularly (i.m.) protected mice against intraperitoneally administered ricin. Furthermore the vaccine without alum was safe and immunogenic in human volunteers. Here we describe the development of gavage and aerosol ricin challenge models in mice and demonstrate that i.m. vaccination protects mice against ricin delivered by either route," wrote J.E. Smallshaw and...

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Source: Vaccine Weekly (2008-01-02)

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