Researchers detail in 'Effects of rapid antigen degradation and VEE glycoprotein specificity on immune responses induced by a VEE replicon vaccine,' new data in vaccines. "Genetic vaccines are engineered to produce immunogens de novo in the cells of the host for stimulation of a protective immune response. In some of these systems, antigens engineered for rapid degradation have produced an enhanced cellular immune response by more efficient entry into pathways for processing and presentation of MHC class I peptides," investigators in the United States report.
"VEE replicon particles (VRP), single cycle vaccine vectors derived from Venezuelan equine encephalitisvirus...
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