DNA Vaccines

Researchers at Emory University have published new data on DNA vaccines

Published in Vaccine Weekly, February 6th, 2008

According to recent research from the United States, "DNA vaccines offer promising strategies for immunization against infections. However, their clinical use requires improvements in immunogenicity."

"We explored the efficacy of Toll-like receptor (TLR) ligands (TLR-Ls) on augmenting the immunogenicity of a DNA prime-modified vaccinia virus Ankara (MVA) boost vaccine against SIV. Rhesus macaques were injected with Fms-like tyrosine kinase 3 (Flt3)-ligand (FL) to expand dendritic cells (DCs) and were primed with a DNA vaccine encoding immunodeficiency virus antigens mixed with ligands for TLR9 or TLR7/8. Subsequently, the animals were boosted with DNA and twice with...

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Source: Vaccine Weekly (2008-02-06)

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