Monoclonal Antibodies
Research results from E.J.F. Prodhomme and co-authors update knowledge of monoclonal antibodies
Published in Vaccine Weekly, February 13th, 2008
According to recent research from Luxembourg, "4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the most abundant and potent procarcinogens in tobacco smoke. In order to induce a strong and substained antibody response against NNK, we developed a functionalized derivative that closely mimicked its structural features, in particular, the pyridyloxobutyl moiety, the adjacent ketone, and the N-nitrosamino group."
"This hapten was conjugated via a C-2 linker to the highly immunogenic diphteria toxoid licensed as a vaccine in humans to induce polyclonal and monoclonal antibodies. Two monoclonal antibodies were obtained with Kd values of 45.8 nM (P9D5) and 37.6...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Vaccine Weekly
Source: Vaccine Weekly (2008-02-13)
More Articles from Vaccine Weekly
- Bird Flu
New vaccine against deadliest strain of avian flu tested by University of Pittsburgh scientists - Whooping Cough
Texas Hospital nation's first to use large-scale 'cocoon strategy' against whooping cough - Immunization
Research in the area of immunization reported from University of Maryland - Immunization
Studies conducted at University of Auckland on immunization recently published - Immunization
Study data from K.R. Niazi and co-authors update knowledge of immunization - DNA Vaccines
Studies in the area of DNA vaccines reported from Academy of Military Medical Science - More from this issue of Vaccine Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
