Immunization

New findings from Ohio State University describe advances in immunization

Published in Vaccine Weekly, February 20th, 2008

According to recent research from the United States, "We inoculated gnotobiotic pigs oraly/intranasally with human norovirus GII.A HS66 strain virus-like particles (VLP) and immunostimulating complexes (ISCOM) or mutant E. coli LT toxin (mLT, R192G) as mucosal adjuvants, then assessed intestinal and systemic antibody and cytokine responses and homologous protection."

"Both vaccines induced high rates of seroconversion (100%) and coproconversion (75-100%). The VLP+mLT vaccine induced Th1/Th2 serum cytokines and cytokine secreting cells, whereas the VLP+ISCOM vaccine induced Th2 biased responses with significantly elevated IgM, IgA and IgG antibody-secreting cells in...

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Source: Vaccine Weekly (2008-02-20)

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