Vaccines
Research findings from University of Natural Resources and Applied Life Sciences update understanding of vaccines
Published in Vaccine Weekly, February 20th, 2008
New research, 'Structural analysis and in vivo administration of an anti-idiotypic antibody against mAb 2F5,' is the subject of a report. "Anti-idiotypic antibody (Ab2) 3H6 is directed against the human monoclonal antibody 2F5, which is one of a few neutralising antibodies against HIV-1. Since the binding epitope of 2F5 is cryptic and no neutralising immune response could be elicited by several potential vaccines comprising this region, Ab2/3H6 represents a potent vaccine candidate for active immunisation," researchers in Vienna, Austria report.
"Here we describe the molecular features of Ab2/3H6 after changing the antigen binding specificity by single point mutations...
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Source: Vaccine Weekly (2008-02-20)
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