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DNA Vaccines
New findings from Y.Z. Yu and co-researchers in the area of DNA vaccines described
March 12th, 2008
According to recent research from Beijing, People's Republic of China, "In current study, the immunogenicity of a plasmid DNA replicon vaccine (pSCARSHc) encoding the He domain of Clostridium botulinum neurotoxin serotype A (AHc) was investigated and compared with a conventional plasmid DNA vaccine (pcDNASHc) encoding the same antigen. In vitro, pSCARSHc incorporating Semliki Forest virus (SFV) replicon could express AHc protein and induce apoptosis of transfected cells." "Comparison with the conventional plasmid DNA vaccine (pcDNASHc) yielded several interesting results. First, our self-designed pSCARSHc could induce relatively higher AHc-specific antibodies and...
Source: Vaccine Weekly (2008-03-12)
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