DNA Vaccines

Scientists at Centers for Disease Control and Prevention report research in DNA vaccines

Published in Vaccine Weekly, March 12th, 2008

According to recent research from Beijing, People's Republic of China, "An effective vaccine strategy for HIV-1 will probably require the induction and maintenance of both Immoral and cellular immunity at mucosal and systemic sites."

"We tested a new prime-boost approach of intranasal priming with 3 x 10(6) PFU of replicative recombinant Tiantan vaccinia virus (rTTV) and intramuscular boosting with 100 mu g DNA plasmid expressing HIV-1 Gag in BALB/c mice along with other strategies. Our data demonstrated that intranasal printing with replicative recombinant Tiantan vaccinia and intramuscular boosting with DNA vaccine raised the highest vaginal IgA and systemic T-cell...

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Source: Vaccine Weekly (2008-03-12)

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