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HIV/AIDS
Findings in HIV/AIDS reported from University of Virginia
March 12th, 2008
A report, 'Inhibition of HIV-1 infectivity through an innate mechanism involving naturally occurring IgM anti-leukocyte autoantibodies,' is newly published data in The Journal of Immunology. According to a study from the United States, "In prior studies, we show that naturally occurring IgM anti-leukocyte autoantibodies (IgM-ALA) bind to CD3, CD4, CCR5, and CXCR4 receptors. These observations prompted us to determine whether IgM-ALA have a role in inhibiting HIV-1 infectivity by inhibiting viral entry into cells." "We show that purified IgM, but not IgG, from individual sera of both normal and HIV-1 infected individuals is highly inhibitory (>95%) to HIV-1...
Source: Vaccine Weekly (2008-03-12)
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