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Immunotherapy
Researchers from Stallergenes SA publish findings in immunotherapy
March 19th, 2008
According to recent research from Antony, France, "IL-10-inducing adjuvants could enhance the efficacy of allergy vaccines in establishing allergen-specific tolerance. The aim of this study was to identify such adjuvants using in vitro cultures of human and murine cells and to evaluate them in a therapeutic murine model of sublingual immunotherapy (SLIT)." "Adjuvants stimulating IL-10 gene expression by human or murine immune cells were tested sublingually in BALB/c mice sensitized to ovalbumin (OVA), assessing the reduction in airway hyper-responsiveness (AHR) by whole-body plethysmography. The induction of regulatory T cells (T-reg) was evaluated using phenotypic and...
Source: Vaccine Weekly (2008-03-19)
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