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Vaccine Weekly

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Bird Flu Vaccines



Studies conducted at Philipps University on bird flu vaccines recently published



March 19th, 2008

Scientists discuss in 'The potential of a protease activation mutant of a highly pathogenic avian influenza virus for a pandemic live vaccine' new findings in bird flu. "The most effective countermeasure against a pandemic originating from a highly pathogenic avian influenza virus (HPAIV) is immunoprophylaxis of the human population. We present here a new approach for the development of a pandemic HPAIV live vaccine," scientists in Germany report.

"Using reverse genetics, we replaced the polybasic hemagglutinin cleavage site of an H7N7 HPAIV with an elastase motif. This mutant was strictly elastase-dependent, grew equally well as the wild-type in cell culture and was...


Source: Vaccine Weekly (2008-03-19)

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