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DNA Research
Research conducted at University of Southampton has provided new information about DNA research
March 19th, 2008
According to a study from Southampton, the United Kingdom, "After priming, naive T cells undergo a program of expansion, contraction, and memory formation. Numerous studies have indicated that only a brief period of antigenic stimulation is required to fully commit CD8(+) T cells to this program." "Nonetheless, the persistence of Ag may modulate the eventual fate of CD8(+) T cells. Using DNA delivery, we showed previously that direct presentation primes high levels of effector CD8(+) T cells as compared with cross-presentation. One explanation now revealed is that prolonged cross-presentation limits effector cell expansion and function. To analyze this, we used a...
Source: Vaccine Weekly (2008-03-19)
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