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Gene Therapy
New data from University of Ulm illuminate research in gene therapy
March 26th, 2008
"Genetic vaccination with adenoviral (Ad) gene transfer vectors requires transduction of professional antigen-presenting cells. However, because the natural Ad receptors are expressed on many cell types, the Ad vectors currently in use are characterized by high promiscuity," scientists writing in the journal Molecular Therapy report. "In fact, the majority of injected Ad vector particles are likely to transduce non-target cells. We have analyzed various sizes of polyethylene glycol (PEG) molecules for vector particle detargeting, and our data provide evidence that the size of the PEG determines detargeting efficiency. With the use of appropriately large PEG...
Source: Vaccine Weekly (2008-03-26)
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