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Hepatitis B Virus
Studies from E. Depla et al add new findings in the area of hepatitis B virus
March 26th, 2008
According to recent research published in the Journal of Virology, "Protein sequences from multiple hepatitis B virus (HBV) isolates were analyzed for the presence of amino acid motifs characteristic of cytotoxic T-lymphocyte (CTL) and helper T-lymphocyte (HTL) epitopes with the goal of identifying conserved epitopes suitable for use in a therapeutic vaccine. Specifically, sequences bearing HLA-A1, -A2, -A3, 424, -B7, and -DR supertype binding motifs were identified, synthesized as peptides, and tested for binding to soluble HLA." "The immunogenicity of peptides that bound with moderate to high affinity subsequently was assessed using HLA transgenic mice (CTL)...
Source: Vaccine Weekly (2008-03-26)
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